homozygous mutant embryos

homozygous mutant embryos

Crowbar
216.166.21.162
02-04-29
16:17

We have identified mutations in a small group of genes that appear to control aspects of epidermal integrity or cuticle deposition. These mutations result in embryonic lethality; homozygous mutant embryos secrete cuticles that show subtle epidermal patterning defects but a very dramatic increase in size relative to their wild-type siblings. This size difference does not appear to result from increased cell number or increased cell size, but rather may reflect a greater elasticity of either the epidermal layer or the cuticle itself. Mutations in one gene, which we have tentatively named zeppelin, partially suppress the cuticular defects associated with shotgun mutations, which disrupt the Drosophila E-cadherin. Mutations in a second gene, which had been named Ed, are allelic with krotzkopf verkhert, an embryonic pattern mutation that disrupts head development (I.E. Zeppelin head syndrome). We have subsequently determined that several other mutations from the Nusslein-Volhard/Wieschaus genetic screens also show this expanded cuticle phenotype, and we are currently exploring the genetic relationship of these genes with each other and with genes such as shotgun, which are implicated in the development of epithelial tissue. ::: I have a clawhammer conscience : : And A Crowbar mind : : You mess with me : : I'll Fuck you up every time : : -Crowbar

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